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Description

Lipid peroxidation in neurodegeneration

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People with type 1 diabetes, and occasionally those with type 2 diabetes, need to take insulin to maintain blood sugar levels

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Specifically, increased expression of peroxisome proliferator-activated receptor- coactivator-1 protein, a key regulator of mitochondrial biosynthesis, disrupts the mitochondrial structure and leads to dysfunctional proliferation, which is involved in the development of certain cardiac diseases, such as heart failure and atherosclerosis (45)

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From a biochemical perspective, this is important

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NF-kB is activated by canonical and non-canonical signalling pathways which has different signalling compounds and its biological functions

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