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Each cohort was then treated for 14 consecutive days with twice-daily treatments with either 300 mg/kg of NHPN-1010 or an equivalent volume of saline

Second, metabolic stress, often accompanied by ATP depletion, limits the cells capacity to reconvert PGA to glutamate via 5-oxoprolinase, resulting in excess PGA being released into the plasma [42]

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Under normal physiological conditions, brain lactate remains relatively stable

Manufacturers of medications need to assess every case of adverse reaction for expectedness, seriousness, and causality