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289 , 290 As an inhibitor of mTOR signaling, metformin resulted in the reduction of cell death and pro-inflammatory cytokines, which might be the main reason for the lower frequency of gout attacks occurred to patients with gout
In addition, we analysed several circulatory intermediates of the methylation cycle (including the methioninehomocysteine, folate, and transsulfuration pathways), which are linked to the methylation of catechol estrogens by COMT
Murrough JW, Mao X, Collins KA, Kelly C, Andrade G, Nestadt P, et al