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Currently, there is no practical way to measure individual NNMT activity to predict response

For deficiency treatments, usually weekly until levels normalize, then monthly maintenance

This system rated cartilage structural integrity from 0, defined as normal to 6, defined as complete disorganization, and assessed cellularity from 0, defined as normal, to 3, defined as hypocellularity, for a total possible score of 0 to 9

Research use therefore focuses on mechanism, target validation, and combinatorial experiments (e.g., with dietary change or NAD precursors) [14,8,9]