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Notably, esophageal, gastric, hepatocellular, and colorectal cancers rank among the top ten tumors causing substantial morbidity, with all five types of DSMTs featuring the top 10 mortality rates [1]

Role of metabolic H2O2 generation: redox signaling and oxidative stress*

However, there are studies indicating that under certain conditions insulin/IGF-1 signaling can provoke pro-inflammatory effects, e.g., through disturbing the Th17/Treg balance in autoimmune diseases [20]