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2017 reported reduced adipose mass in diet-induced obese mice without changes in food intake

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Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Wrbel H (2020) The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Collectively, these factors result in exceedingly low bioavailability, defined as the fraction of the ingested compound that reaches systemic circulation in an active form, thereby limiting the therapeutic and nutritional efficacy of such agents