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Blood work should be checked to rule out thyroid dysfunction, iron deficiency, and other medical causes

62 It also appears to have blood vessel-constricting effects and may be useful in topical formulations for rosacea

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Further support comes from cross-sectional studies comparing PD and matched control subjects 13 , while others have investigated the role of UA in disease progression and severity, with findings suggesting an influence of low UA in each of these clinical factors 14,15

31 Tissue culture studies also show curcumin to inhibit the breakdown of the extracellular matrix in cartilage cells when stimulated by interleukin- and helps protect arthritic joints from destruction, 32 preventing osteoclast formation, 33 and inhibiting interleukin induced degradation of the extracellular matrix and release of glycosaminoglycan