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Without adequate B12, these processes begin to function sub-optimally and the effects, while not always dramatic in the early stages, accumulate in ways that many people experience as persistent tiredness, reduced mental sharpness, lower mood and a general lack of the vitality they feel they should have

une mthionine synthase dficiente pige donc le folate et altre la synthse de lADN, ce qui est lorigine des modifications mgaloblastiques observes dans la carence en B12

[DOI] [PubMed] [Google Scholar] 90.Akerfelt M., Trouillet D., Mezger V., Sistonen L

Haematologica 97 , 827834 (2012)

This observation highlights a recurring theme