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Keywords: roflumilast, methotrexate, hepatotoxicity, glutathione, malondialdehyde, tumor suppressor protein-53, interleukin 6, interleukin 1 Introduction Drug-induced liver toxicity is a major limitation of pharmacotherapy, which can lead to fatal adverse drug reactions and incidence of morbidity and mortality

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doi:10.1177/0363546520937293 23 Hurley ET, Shimozono Y, Hannon CP, Smyth NA, Murawski CD, Kennedy JG

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