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Currently, GPx3 is considered a new tumor-suppressor gene [23], and its hypermethylation, which is associated with the further down-regulation of GPx3, was observed in patients with Barretts esophagus [54], endometrial adenocarcinoma [55] and prostate cancer [56]

It is also common to see a drop in thyroid function as well which is the metabolic engine for the body