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Notably, tirzepatide is characterised in the literature as an imbalanced or biased dual agonist: its affinity for the GIP receptor is comparable to native GIP, while its affinity for the GLP-1 receptor is roughly 18- to 20-fold weaker than native GLP-1

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Electrophilic phytochemicals, such as SFN, modify distinct cysteine residues from those affected by oxidative stress [24], allowing the phytochemicals to further upregulate NRF2 activity and mitigate adverse outcomes of external insults [28, 29]