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Nevertheless, the remyelination of damaged axons remains possible and may promote axonal recovery and, thus, neuronal survival (Schultz et al., 2017)

Hispidulin is effective in inhibiting c-fos and major MAPKs (ERK1/2, p38, JNK), thereby reducing microglial activation and the production of pro-inflammatory cytokines, consequently diminishing seizures and hippocampal inflammation (Lin et al., 2015)

This modification enables IGF-1 LR3 to serve as a superior model for examining IGF-1 receptor (IGF-1R) signalling and downstream activation of PI3K/Akt and MAPK pathways in controlled studies