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Only six reproducible, genome-wide significant loci have been identified: CHRNB3-CHRNA6 (chr8p11), DBH (chr9q34), CHRNA5-CHRNA3-CHRNB4 (chr15q25), DNMT3B and NOL4L (chr20q11), and CHRNA4 (chr20q13) 6

Chronic inflammation increases the risk of potentially deadly diseases, while oxidative stress which results from an imbalance between cell-damaging molecules called free radicals and antioxidants, which fight free radicals can lead to cardiovascular, pulmonary, neurological and other diseases, including cancer

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