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Patients should be counseled about symptoms requiring immediate medical attention and advised to avoid pregnancy while on these medications, discontinuing them prior to planned conception

Is the treatment safe, and are there side effects

Patients should maintain realistic expectations and commit to lifestyle modifications for optimal results

Because of the lack of stable 3D-structures, IDPs can sustain exposure to extremely harsh environmental conditions that would typically denature or unfold ordered proteins and render them dysfunctional (Uversky, 2017b)