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Recently, a high-resolution crystal structure of phosphinic pseudopeptide inhibitor 45 (DG046) in the closed-conformation of ERAP1 was disclosed (Giastas et al., 2019b) and a mechanism for antigen peptide selection by ERAP1 presented ( In 2015, Papakyriakou et al

doi: 10.1016/j.mri.2019.03.020, 4 CabrR.NaudA.Dominguez-GonzalezM.AyalaV.JovM.Mota-MartorellN.et al

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Abstract Nitrogen detoxification pathways in the central nervous system supply a range of neurotransmitters, ranging from long-appreciated examples like nitric oxide and agmatine, to emergent neurotransmitters including spermidine, spermine, and polyamine-derived GABA