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References to metabolic or adipose-related pathways are included for scientific context only and do not imply therapeutic or clinical outcomes

Williams' group was the first one officially accepted for screening by the NIH Roadmap Molecular Libraries Initiative

Neuroscience 145 (1), 256264

These proinflammatory molecules also induce the above lesions through the nuclear factor-B (NF-B), Janus kinase/signal transducers and activators of transcription (JAK/STAT), and TGF-/Smad signaling pathways[99-101]

By neutralizing these damaging agents, it helps slow down the aging process, reducing the formation of wrinkles, fine lines, and other signs of premature aging