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Although the protection against necrosis was still present at 24 h, there was clear evidence of a limited number of apoptotic cells and caspase activation [58]

In response to NO and peroxynitrite, MTs release Zn, which induces MTF-1, and this increases the expression of protective genes by scavenging some ROS and reactive nitrogen species [147]

[DOI] [PMC free article] [PubMed] [Google Scholar] 107.Tardiolo G., Bramanti P., Mazzon E