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A separate 2013 review in the peer-reviewed journal Alcoholism: Clinical and Experimental Research synthesizing how alcohol consistently reduces slow-wave sleep duration and disrupts the nighttime endocrine pulse pattern reaches the same conclusion across multiple study populations

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A 2025 systematic review and meta-analysis of 12 studies (6,645 participants) confirmed significant correlations between klotho levels and cognitive function, supporting its potential as both biomarker and therapeutic target