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Additionally, the IGF-1/IGFBP-3 ratio, a common rough of free IGF-1 levels, is significantly decreased in obesity [216], however no IGF-1 bioactivity was estimated

Shi S, Lei S, Tang C, Wang K, Xia Z (2019) Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway

A handful of clinical trials have investigated the effects of methylene blue in treating aspects of Alzheimers disease in people, but a 2023 review of these trials notes that their results have been mixed and not conclusive