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Amylin and Cagrilintide activate CGRP-like neurons in the AP that project to: Nucleus tractus solitarius (NTS) , autonomic center Parabrachial nucleus , integration of taste and satiety Hypothalamic pathways , energy balance The result: strong central appetite suppression and stabilization of satiety between meals

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For a 250 mcg dose, this requires drawing 0.1 mL (10 units on an insulin syringe) of the reconstituted solution

FIGURE 3 Overall, the ligand-based pharmacophore models present strength in terms of high recall and ROC AUC values, suggesting their potential utility in identifying novel active compounds