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The cohort born between 19551965 (aged 3544 years in 2000) was the first cohort to experience a significant decline in smoking prevalence, from 32.0% in 2000 to 21.1% in 2020, while the cohort born before that time remained almost stable over time [27]

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The serum of active smokers shows higher levels of TNF- and IL-1 compared to the serum of nonsmokers as well as a greater ability to induce ROS production and COX-2 expression in endothelial cells [142]

Reynolds because they did not meet the agency's safety review requirements

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