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The polyubiquitin chain, which is essential for degradation of most substrates by the 26S proteasome, is formed through isopeptide bonds between the carboxyl terminus of Gly76 of one ubiquitin and the amino group of the lysine residues at positions 48 (K48) of another ubiquitin molecule (Chau et al., 2007) and mice (Irmler et al., 2002

Numerous studies have shown that physical therapy can significantly decrease pain and improve function in individuals with carpal tunnel syndrome

doi: 10.1016/j.jare.2020.07.007 157 DingCDingXZhengJWangBLiYXiangHet al

Journal of neuroscience research