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In non-enzymatic processes, the H 2 O 2 combines with Fe 2+ (e.g., ferritin protein) or Cu 2+ (e.g., ceruplasmin protein) ions in the Fenton reaction, where it accepts an electron from metal ions to form highly reactive (t 1/2 = 10 9 s) HO radical and HO + ion and thus are highly reactivity in the mitochondrial matrix [16]

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The omics technologies have provided scientists with the ability to better characterize the phenotypes of patients and to discover biomarkers of diseases (Wood et al