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DSIP: DSIP has limited human safety data from small clinical studies

Understand each method's dose range independently

Superiority testing followed a hierarchical order, beginning with the highest Cagrilintide dose versus placebo, using a two-sided 5% significance threshold

Jerome MS, Kuthethur R, Kabekkodu SP, Chakrabarty S (2022) Regulation of mitochondrial function by forkhead transcription factors

Mol Biol Rep 48(9):65396550 Tibullo D, Li Volti G, Giallongo C, Grasso S, Tomassoni D, Anfuso CD, Lupo G, Amenta F, Avola R, Bramanti V (2017) Biochemical and clinical relevance of alpha lipoic acid: antioxidant and anti-inflammatory activity, molecular pathways and therapeutic potential