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Reviews that focus on phytochemicals emphasize mechanisms and preclinical efficacy, while nanoparticle reviews cover transport strategies and materials science, and few syntheses explicitly integrate nano-design variables with BBB transport outcomes for phytochemicals (26, 27)

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In the case of -sheets, Gly allows sterically-unhindered hydrogen bonding between the amino and carboxyl groups of peptide bonds on adjacent protein chains, facilitating their close alignment and strong binding

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PLoS One 11 , e0163214 (2016)