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A separate 2025 narrative review by McGuire and colleagues asked a blunter question in its title: "Regeneration or Risk?" [2] Their conclusion: the preclinical evidence is consistently positive, but the absence of human data makes it impossible to generate evidence-based practice guidelines

Kondori, N., Edebo, L

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That changed in 2017, when researchers confirmed the presence of Epitalon in native pineal gland extracts, a discovery that validated its endogenous origin and helped explain its overlap with, but also differences from, Epithalamin [7]