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18 Estrogen-only therapy (for women without a uterus) was associated with lower breast cancer incidence and mortality Estrogen plus progestin therapy showed a slight increase in breast cancer incidence, but no increase in breast cancer mortality Additional reviews examining hormone therapy in women with a history of breast cancer found no increase in breast cancer mortality , with only one study showing increased local recurrence, not distant spread or death

Blher M, Aras M, Aronne LJ, et al

2019 Nov 22 [cited 2021 Dec 1]

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Dihexa has no FDA approval for any indication it remains restricted to preclinical research use