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Lipid peroxidation stands out as one of the most critical outcomes of oxidative stress affecting sperm function

It should not be described as the complete pineal extract or as a pineal hormone

The Phase I trial of the novel HDAC inhibitor Bisthianostat (BIS, oral tablets, starting dose of 100 mg, escalated to 200/400 mg, administered twice weekly) demonstrated good safety as a monotherapy, with no Grade 3/4 non-hematologic toxicities

Although these data suggest safety of use, PPIs should be used during pregnancy with medical supervision and only in women with complicated GERD refractory to other therapies