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Laboratory studies demonstrate that FOXO4-DRI effectiveness depends on senescent cell burden, tissue type, and the specific mechanisms maintaining senescent cell viability in different experimental conditions

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Looking ahead, the integration of precision nutrition approaches, accounting for the gut microbiome, HLA genotype, and individual variability in metabolic response to the GFD, may enable increasingly tailored interventions, enhancing therapeutic efficacy and reducing the risk of MetS and cardiometabolic complications in children and adolescents with CD

M., & Aggarwal, B

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