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Nevertheless, the metabolic consequences of IR, including hyperglycemia and dyslipidemia, can interact synergistically with these mechanisms to worsen vascular risk [925]
They add that as immunotherapies are being more commonly utilized as first- and second-line treatments, immunotoxicity and autoimmunity are emerging as the Achilles heel of immunotherapy. In their Cancer Immunology Research paper, Bluestone and colleagues briefly discuss immunotherapeutic strategies that can potentially prevent irAEs, such as targeting intratumoral T cells directly, using bispecific antibodies to enhance localized targeting of tumor, and using engineered cell therapies to fine-tune immune cell responses
The method of embodiment 159, wherein the drug-induced ototoxicity is chemotherapy-induced ototoxicity
We previously demonstrated that a 1-week IGF-1 LR3 infusion into fetal sheep reduces in vivo and in vitro insulin secretion suggesting an intrinsic islet defect
