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Diagnostic value of blood coenzyme Q10 levels in children with mitochondrial diseases

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The glutamate produced from glutamine is converted to 2-oxoglutarate (-ketoglutarate) via the action of glutamate dehydrogenase (making glutamine a glucogenic amino acid) and yielding another mole of NH 4 +

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Although the details of the sodium channel dysfunction differ depending on the individual mutation site, overall changes are made toward channel hyperactivity, promoting neuronal hyperexcitation [32,33,34,35]