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Too little and you are working with concentrations so high that tiny measurement errors become magnified into real dosing problems

B12 shots might benefit people dealing with: Constant tiredness Low blood cell counts Trouble digesting Pernicious anemia Low nutrient levels Struggles with weight loss A study showed that injecting B12 into the muscle raised levels in the blood faster and kept them higher for longer than taking B12 by mouth in those with absorption problems

Dosing regimens have ranged from 350 g per week (in vegetarians) to 2000 g per day in a study including patients with pernicious anaemia, with the most common daily dose being 1000 g per day

For microdosing protocols , some researchers add 2.5 mL to a 5 mg vial, creating a 2 mg/mL solution