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doi: 10.1152/ajplung.1999.277.6.L1142 124 PostMBarsoumianASmithBT

Edaravone was also used in combination with the anti-inflammatory drug dexborneol and showed promising results in clinical trials of stroke

In this context, caffeine, through its dual role as an ADORA2b antagonist and a direct inhibitor of G6PD (the rate-limiting enzyme of the PPP), emerges as a double-edged metabolic modulator