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PLGA nanoparticles coated with baicalin and the melanoma antigen Hgp peptide fragment 25-33, prepared using ultrasound double-emulsion technology and further loaded with CpG fragments and forming a nanocomposite on their surface with conjugated M2pep and -pep peptides, can be effectively taken up by M2 TAMs and convert M2-like TAMs into M1-like phenotypes thereby remodeling the TME and killing tumor cells (56)

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As a comparative measure, pSiNP modified with bovine serum albumin (BSA@pSiNP) displayed analogous attributes, including size (172 4 nm) and zeta potential (-9.9 4.4 mV)