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His colleague Shin-ichiro Imai, a professor of developmental biology at the Washington University School of Medicine who first met Sinclair in Guarentes lab, says Sinclair had a keen eye for capturing novel concepts and, based on that foundation, building new lines of research faster than anyone else. At the time, aging research, once considered a fringe science, was still in its infancy, but Sinclair was determined to propel it to legitimacy

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That is, the residual amount was different only at the inflamed site