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Understanding Hyperpigmentation and Its Causes Hyperpigmentation represents one of the most common skin concerns affecting individuals worldwide, manifesting as dark patches, spots, or uneven skin tone that can significantly impact confidence and appearance

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These can further disrupt intestinal barrier permeability, aggravate the systemic pro-inflammatory state, impair bloodbrain barrier permeability and recruit immune mediators leading to neuroinflammation and neurodegeneration

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Wang C, Xia Y, Zheng Y, Dai W, Wang F, Chen K, Li J, Li S, Zhu R, Yang J, Yin Q, Zhang H, Wang J, Lu J, Zhou Y, Guo C (2015) Protective effects of N-acetylcysteine in concanavalin A-induced hepatitis in mice