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The half-life of NO and therefore its biological activity is decisively determined by oxygen-derived free radicals such as superoxide anions, 32 which as mentioned above rapidly bind to NO to form the highly reactive intermediate ONOO

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Furthermore, expression of both the glutathione synthesis genes GSH1 and GSH2 was greater in the D-HIS-selected population, consistent with these cells higher production of GSH (Fig

10.1126/scitranslmed.aan8162 Sci

There are enzymes and molecules in the body that serve as antioxidants such as superoxide dismutase (SOD), catalase, glutathione peroxidase and glutathione which removes ROS molecules from the living system