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As previously noted, ROS activate the NFKB signalling pathway [17, 25]

Tirzepatide, the GLP-1 in Zepbound and Mounjaro, pushed Eli Lilly past US$1 trillion in market capitalization on November 21, 2025 the first healthcare company in history to cross that threshold

This suggests a potential role in conditions characterized by neurotransmitter dysregulation

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B12 levels can decrease with age, as well as being lower in people who have undergone weight loss surgery, or suffer from multiple sclerosis, pernicious anaemia, Crohns or celiac disease