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In preclinical models, leaky tumor vessels and impaired lymphatic drainage can support higher local retention of long-circulating particles

Mol Cell Biol 16 : 11151125 Johnson BE, Fischer T, Fischer B, Dunlop D, Rischin D, Silberman S, Kowalski MO, Sayles D, Dimitrijevic S, Fletcher C, Hornick J, Salgia R, Le Chevalier T (2003) Phase II study of imatinib in patients with small cell lung cancer

6,350,467, references the use of glutathione and ascorbic acid to influence the redox status of cells in disease states, however does not reference the use of a liposome encapsulation to deliver and maintain the glutathione in the reduced state to the system

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Chang, F