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The cytoplasmic accumulation of PFKFB3 promotes its phosphorylation by AMPK, leading to PFKFB3 activation and enhanced glycolysis

Although folic acid supplementation has been proven effective to control circulating homocysteine concentrations, homocysteine lowering has not affected the incidence of cardiovascular disease in supplementation trials

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The major sensitivity of mitochondrial DNA to ROS-induced mutagenesis is intuitive, as this DNA is not protected by histones, and mitochondria lack the nucleotide excision repair (NER) enzymatic system