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Lactate accumulation leads to acidification of the extracellular environment, which impairs the function and viability of cytotoxic immune effector cells, particularly CD8+ T cells and natural killer (NK) cells

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He is asymptomatic and has no ascites, encephalopathy, or evidence of bleeding in the gastrointestinal tract

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies