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It plays key roles in mammalian metabolism and physiology, with important roles in the function of tissues including liver, muscle, white and brown adipose tissue, and the brain

However, a clinical trial with aducanumab failed to reduce cognitive deficits (Pardridge, 2019)

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This protection reduces unnecessary apoptosis a form of programmed cell death that, when excessive, can deplete healthy cells and weaken tissues.16 TUDCA clearly alters bile chemistry under cholestatic stress, but most evidence for its cellular effects still comes from cell and animal studies

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