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Proteolytic activation of jr PPO1-wt In vivo activation of PPOs is achieved by cleavage in-between the C- and N-terminal domain 45

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According to the press release, the Phase 3 study demonstrated that SPI-1005 had significantly reduced vertigo frequency, improved patient-reported outcomes for hearing and tinnitus in individuals with Mnires disease

Epidemiology APAP is one of the most commonly used analgesics in the United States and reportedly the most common cause of acute liver failure in the United States