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Muscular contraction, nerve impulses, skeletal integrity, and a variety of metabolic reactions depend on very specific concentrations of electrolytesparticularly sodium, potassium, chloride, magnesium, calcium, and bicarbonate (Rizzoli 2014

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Furthermore, p-JNK leads to the activation of Bax and translocation to mitochondria to trigger the mitochondrial permeability transition (MPT) pore formation, along with collapsed ATP depletion and membrane potential, eventually causing DNA fragmentation and necrosis (Kim et al., 2006)

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