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Lentiviral-based transfection into HaCaT cells For suppression of NRF2 in HaCaT cells, lentiviral particles expressing shRNAs against human NRF2 were used to downregulate NRF2 mRNA

NikolausSSchulteBAl-MassadNThiemeFSchulteDMBethgeJet alIncreased tryptophan metabolism is associated with activity of inflammatory bowel diseases

It activated the SLC7A11/GPX4 signaling pathway, upregulated GSH-Px and GSH expression, decreased MDA and ferroptosis levels, and inhibited lipid peroxidation and ferroptosis in the cerebral cortex, thereby improving motor function, balance, and neurological deficits in the rats

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Macrophages and monocytes release mediators of OS that degrade the unsaturated fatty acids