M1 secretes pro-inflammatory cytokines (mainly IL-1, IL-6, and TNF), which lead to osteoclast (OC) activation and joint erosion, and M2 produces anti-inflammatory cytokines such as IL-10 and transforming growth factor- (TGF-) to promote angiogenesis and tissue remodeling [82, 83]
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HepG2 cells develop signs of riboflavin deficiency within 4 days of culture in riboflavin-deficient medium
What separates it from older GH secretagogues like GHRP-6 or GHRP-2 is its receptor selectivity it triggers GH release without significantly elevating cortisol, prolactin, or ACTH