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To survive and establish infection, they have developed a robust antioxidant defense system, including catalases, superoxide dismutases (SODs), glutathione peroxidases (GPxs), and peroxiredoxins (Leal et al., 2012

The GDH2 complex is not inhibited by GTP which allows astrocyte GDH2 to continue to function under conditions of intense excitatory neurotransmission allowing these cells to handle the increased loads of the neurotransmitter glutamate