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On the other hand, Sirtuin-3 can also deacetylate and activate mitochondrial proteins involved in the elimination of ROS (Xu et al., 2016a

Biochemically, ferroptosis involves iron dysregulation, ROS accumulation, mitochondrial dysfunction, glutathione (GSH) depletion, and lipid peroxidation (Liu et al., 2025)

To test whether the observed reduction in PhoA activity is dependent on glutathione levels in the periplasm, we also measured PhoA activity in a cydD mutant

Combined, they're known in the peptide research community as the Wolverine Stack because together they target multiple dimensions of the healing process that neither covers alone

C., Fenselau, C