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Post-immunotherapy radiotherapy synergizes with IFN, further promoting ferroptosis via SLC7A11 inhibition (83)
A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007
EGCG was also identified to differentially inhibit TNF- and LPS-mediated activation of NF-B (Zhang et al., 2010a), the key factor of NF-B pathway
4) All of this is followed by Dr
doi: 10.1007/s13346-019-00698-z
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