A 1 mL solution has 1000 mcg of Vitamin B12
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There is extensive enterohepatic circulation of vitamin B12, and then B12 is transported from the liver, via the bile duct, to the duodenum
45,46 As shown in Figure 2 , GLP-1RAs penetrate the blood-brain barrier and directly activate GLP-1 receptors in the hypothalamus, especially within the ARH nucleus, a key center for appetite regulation